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Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing
Affiliation:1. Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul 34734, Turkey;2. Department of Molecular Biology and Genetics, Koc University, Istanbul 34450, Turkey;3. Department of Medical Biology, School of Medicine, Bahcesehir University, Istanbul 34734, Turkey;4. Department of Chemistry, Gebze Technical University, Kocaeli 41400, Turkey;5. Department of Molecular Biology - Genetics and Biotechnology, Istanbul Technical University, Istanbul 34469, Turkey;6. Neuroscience Program, Graduate School of Health Sciences, Bahcesehir University, Istanbul 34734, Turkey;7. School of Medicine, Bahcesehir University, Istanbul 34734, Turkey;8. Faculty of Medicine, Mersin University, Mersin 33070, Turkey;9. Deutsches Elektronen-Synchrotron, Notkestrasse 85, Hamburg 22607, Germany;10. Department of Physics, Arizona State University, Tempe, AZ 85287-1504, USA;11. Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ 85287-5001, USA;12. Stanford PULSE Institute, SLAC National Laboratory, Menlo Park, CA 94025, USA;13. Linac Coherent Light Source, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, USA;14. Department of Applied Physics, Stanford University, Stanford, CA, USA;15. Hauptman-Woodward Medical Research Institute, University at Buffalo, 700 Ellicott St, Buffalo, NY, USA;16. Materials Design and Innovation, SUNY at Buffalo, 700 Ellicott St., Buffalo, NY, USA;17. Koc University Isbank Center for Infectious Diseases (KUISCID), 34450, Istanbul, Turkey
Abstract:
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  • Keywords:SARS-CoV-2  SFX  ambient temperature  drug repurposing  main protease
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