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Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors |
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| Authors: | Poorval M. Joshi Shari L. Sutor Catherine J. Huntoon Larry M. Karnitz |
| Affiliation: | From the ‡Department of Molecular Pharmacology and Experimental Therapeutics and ;§Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905 |
| Abstract: | |
| Keywords: | BRCA1 CDK (Cyclin-dependent Kinase) DNA Damage Homologous Recombination Ovarian Cancer CDK12 Cisplatin Poly(ADP)-ribose Polymerase RAD51 Veliparib |