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Poly(ADP-ribose) polymerase-1 inhibition protects the brain against systemic inflammation |
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| Authors: | Czapski Grzegorz A Cakala Magdalena Gajkowska Barbara Strosznajder Joanna B |
| Affiliation: | aDepartment of Cellular Signalling, Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., PL-02106 Warsaw, Poland bDepartment of the Cell Ultrastructure, Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., PL-02106 Warsaw, Poland |
| Abstract: | Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA repair, but its overactivation can induce cell death. Our aim was to investigate the role of PARP-1 in activation of programmed cell death processes in the brain during systemic inflammation. Our data indicated that lipopolysaccharide (1 mg/kg b.w., i.p.)-evoked systemic inflammation enhanced PARP-1 activity in the mouse brain, leading to the lowering of β-NAD+ concentration, to translocation of apoptosis inducing factor from mitochondria to the nucleus, and to enhanced lipid peroxidation. Inhibitor of PARP-1, 3-aminobenzamide (30 mg/kg b.w., i.p.), protected the brain against prooxidative and cell death processes, suggesting involvement of PARP-1 in systemic inflammation-related processes in the brain. |
| Keywords: | Inflammation Oxidative stress Poly(ADP-ribose) polymerase-1 Apoptosis |
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