Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity |
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| Authors: | Hirata K Ito C Furukawa H Itoigawa M Cosentino L M Lee K H |
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| Affiliation: | Faculty of Pharmacy, Meijo University, Nagoya, Japan. |
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| Abstract: | 
Several substituted 7H-pyrido[4,3-c]carbazoles were synthesized from the natural product mukonal and tested for inhibition of HIV replication in H9 lymphocytes. 5-Methoxy-7-methyl-7H-pyrido[4,3-c]carbazole (7) had an EC50 value of 0.0054 microgram/mL and the highest therapeutic index (TI = 503) in the series. |
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