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Impact of transient stress and stress enzymes on development
Authors:Rappolee D A
Institution:CS Mott Center for Human Growth and Development and Department of Ob/Gyn, Wayne State University School of Medicine, 275 East Hancock, Detroit, MI 48201, USA. drappole@med.wayne.edu
Abstract:Stress enzymes triggered by transient stress mediate reprioritization of developmental and homeostatic events to flexibly accomplish the next essential developmental event. This review analyzes recent studies on stress and stress enzyme function during early mammalian development and describes the diverse consequences that result from measurement, analysis of function, and management of stress and stress enzymes during development.
Keywords:Stress  Stress enzymes  Embryonic stem cells  Trophoblast stem cells  Blastocyst  Implantation  Hypoxia  FGF  Oct4  Cdx2  Polycombs  SAPK/JNK1/2  P38MAPK  ERK/MAPK7  JAK  Fetal origins of adult disease (FOAD)
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