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医院感染葡萄球菌的耐药性及D-试验研究分析
引用本文:王潭枫,符振华,吴宗华. 医院感染葡萄球菌的耐药性及D-试验研究分析[J]. 中国微生态学杂志, 2009, 21(9): 848-849
作者姓名:王潭枫  符振华  吴宗华
作者单位:中山大学附属第三医院,检验科,广东广州510630
摘    要:目的了解医院感染葡萄球菌的耐药性及克林霉素诱导试验(D-试验)临床意义。方法从住院患者标本中分离到的539株葡萄球菌进行药敏试验和D-试验,所得结果进行统计分析。结果葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MPSE)的检出率高,分别为65.1%和83.6%,各种葡萄球菌对万古霉素敏感率为100%,对阿奠西林头孢菌素在内的各种β-内酰胺酶类抗生素敏感率低于35%,对红霉素耐克林霉素敏感的D-试验阳性率为57.O%。结论葡萄球菌耐甲氧西林检出率,呈多重耐药,在选用大环内酯类,克林霉素类抗生素时要注意D试验,合理用药,提高疗效。

关 键 词:葡萄球菌  耐药性  医院感染  D-试验

Resistance of staphylococcus and D-test analysis in nococomial infection
WANG Tan-feng,FU Zhen-hua,WU Zong-hua. Resistance of staphylococcus and D-test analysis in nococomial infection[J]. Chinese Journal of Microecology, 2009, 21(9): 848-849
Authors:WANG Tan-feng  FU Zhen-hua  WU Zong-hua
Affiliation:( The Third Affiliated Hospital of Sun Yat-sen Uniuersity,Gungshou,510630,China)
Abstract:Objective To investigate the resistance of staphylococcus in nocomial infection and evaluate the clinical value of inducible clindamycin resistance (D-test). Method D-test and drug resistance experiments were applied in 539 strains of staphylococci isolated from in-patients with statistical analysis. Result Of all 539 staphylococcus strains ,351 strains(65.1% ) were MRSA,450 strains (83.6%) were MPSE. All strains were sensitive to vancomycin. The percentage of sensitivity to β-lactamase antibiotics including amoxicillin was no more than 35%. D-test positive rate was 57.0% of which were erythromycin resistant but clindamycin sensitive. Conclusion The ratio of MRSA in staphylococcus strains is rather high. , which show character of multipdrug resisteance. D-test for detection of inducible resistance of erythromycin to clindamycin in staphylococcus strains should be checked in clinical microbiology laboratory, which could help the physicians to choose correctly the antibiotics such as macrolide and clindamycin.
Keywords:Staphylococcus  Drug resistance  Nococomial infection  D-test
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