First cyclotide from Hybanthus (Violaceae) |
| |
Authors: | Broussalis A M Göransson U Coussio J D Ferraro G Martino V Claeson P |
| |
Institution: | Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina. |
| |
Abstract: | Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS(2). Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus, and now propose a uniform nomenclature for cyclotides. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|