EGFR、HER2、CXCR4在tied,细胞肺癌中的表达及临床意义

目的：研究EGFR（epidermal growth factor receptor）、HER2（ human epidermalgrowth factor receptor-2）及CXCR4（chemokine（C-X-C motif） receptor 4）在NSCLC 中的表达，分析它们与NSCLC 临床病理特征的的关系。方法：选择我科2009 年7 月-2012年12 月收治的75 例非小细胞肺癌（NSCLC）患者为研究对象，支气管镜活检得到NSCLC肿瘤组织标本,免疫组织化学技术分别检测EGFR、HER2、CXCR4在NSCLC 组织中的表达，并分析EGFR、HER2、CXCR4 的表达与NSCLC 患者临床病理指标和生存期的相关性。结果：EGFR、HER2 及CXCR4在NSCLC中的表达与患者淋巴转移及远处转移有关（P〈0.05）。EGFR、HER2 及CXCR4在NSCLC 中的表达均呈正相关，EGFR 与HER2，EGFR 与CXCR4，HER2 与CXCR4 的相关系数分别为r=0.296（P〈0.01），r=0.578（P〈0.01），r=0.426（P〈0.01）。3 种基因表达越多，患者中位生存时间越短（P〈0.05）。结论：EGFR、HER2 及CXCR4 与NSCLC的发生发展关系密切，针对性的多个靶向抑制，可更好发挥抑癌作用。根据三者不同的表达情况初步筛选出针对靶向治疗的单一或联合靶点，有助于为NSCLC 患者提供个体化的治疗方案。为进一步治疗提供依据。

Expression and Clinical Significance of EGFR,HER2 and CXCR4 in Non-small Cell Lung Cancer

Objective： To investigate the expression of EGFR（epidermal growth factor receptor）, HER2（ human Epidermal growth factor receptor-2） and CXCR4 （chemokine （C-X-C motif） receptor 4） in NSCLC and analyze their relationship with clinicopathological features of Non-small cell lung cancer （NSCLC）. Methods： 75 cases of NSCLC admitted in our hospital from July 2009 to December 2012 were selected, and the expressions of EGFR, HER2 and CXCR4 in NSCLC tissues from hronchoscopic biopsy were detected by immunohistochemical technique. The correlation between EGFR, HER2 and CXCR4 expression and clinicopathological features as well as survival was analyzed. Results： The positive EGFR, HER2 and CXCR4 expression in NSCLC was significantly correlated with lymph node metastasis and distant metastasis （P〈0.05）. The correlation of EGFR, HER2 and CXCR4 expression were positively. The correlation coefficient of EGFR, HER2 and CXCR4 respectively was r=0.296 （P〈0.01）, r=0.578 （P〈0.01）, r=0.426 （P〈0.01）. Survival period of EGFR, HER2 and CXCR4 in positive cases were significantly shorter than negative cases; and the more positive expression, the shorter survival time （P〈0.05）. Conclusion： Upregnlation of the EGFR, HER2 and CXCR4 expression was closely related with NSCLC metastasis and prognosis. These three proteins which was inhibited may play a better suppressor role. Under the different expression of the three proteins can screeed a single or combinated therapeutic target, which is benefit for NSCLC patients to provide individualized therapy and the further treatment basis.