参麦注射液对于白血病骨髓抑制期的治疗作用

目的：探讨参麦注射液对于白血病骨髓抑制期的治疗作用。方法：选取我院2011 年1 月至2012 年12 月收治的白血病的患者47 例，随机分为两组，观察组24 例化疗的同时给予参麦注射液，观察组患者23 例只给予化疗，比较两组患者化疗后的骨髓抑制情况和感染发生情况。结果：两组患者化疗效果显示总有效率分别为66.7%和65.2%，无显著差别（P〉0.05）。两组患者化疗骨髓抑制后WBC, Hb, PLT 的恢复时间分别为（6.32± 2.75）天，（9.32± 2.12）天和（7.31± 3.21）天，明显低于对照组（11.34± 4.34）天，（12.54± 3.21）天和（12.41± 4.32）天，差异显著有统计学意义（P〈0.05）；观察组患者中性粒细胞ANC〈0.5× 10^9/L持续的时间明显少于对照组，差异明显有统计学意义（P〈0.05）；观察组患者发生感染的比例明显低于对照组，差异显著有统计学意义（P〈0.05）。结论：参麦注射液可以明显减轻白血病化疗后的骨髓抑制现象，有效保护骨髓的造血功能，缩短骨髓受抑制时间，和降低感染率，明显提高患者生活质量。

Clinical Effect of Shenmai on the Treatment of Myeloid Leukemia with Bone Marrow Inhibition

Objective： To study the clinical effect of Shenmai on the myeloid leukemia with bone marrow inhibition. Methods： 47 cases of leukemia who were treated in our hospital from January 2011 to December 2012 were selected and randomly divided into two groups, namely, the observation group （24 cases） and the control group （23 cases）. Patients in the observation group were given chemotherapy combined with Shenmai while patients in the control group were given chemotherapy. Then the suppression of bone mar- row were compared between two groups after chemotherapy. Results： The efficacy rate of the observation group was 66.7%, the efficacy rate of the control group was 65.2%, and there was no statistically significant difference between two groups （P〉0.05）. The duration of the myeloid suppression period （WBC, Hb, PLT lower than normal level） （6.32± 2.75）, （9.32± 2.12） and （7.31± 3.21d） in the observation group which were shorter than those of the control group （11.34± 4.34）, （12.54± 3.21） and （12.41± 4.32d）, and there was statistically significant difference between two groups （P〈0.05）; the period ofneutrophils ANC 〈 0.5× 10^9/L in the observation group was less than that of the control group, and there was statistically significant difference between two groups （P〈0.05）; the infectious rate of the observa- tion group was lower than that of the control group, and there was statistically significant difference between two groups （P〈0.05）. Con- clusion： Shenmai injection can significantly reduce the leukemia bone marrow suppression after chemotherapy, effectively protect the bone marrow hematopoietic function, shorten the time of bone marrow suppression, and reduce the infection rate, improve patient quality of life.