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Synthesis of lipid A type carboxymethyl derivatives with ether chains instead of ester chains and their LPS-antagonistic activities |
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| Authors: | Watanabe Yukiko Miura Kumiko Shiozaki Masao Kanai Saori Kurakata Shin ichi Nishijima Masahiro |
| Institution: | Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan. |
| Abstract: | Synthesis of lipid A type carboxymethyl derivatives having ether chains at both the C-3 and C-3' positions and their LPS-antagonistic activities toward human U937 cells are described. |
| Keywords: | Lipid A Endotoxin LPS-agonist LPS-antagonist TNFα production inhibitor |
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