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Influence of the culture conditions of brucella abortus on its antitumor properties |
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| Authors: | B. Collet L. Dazord J. Portoukalian F. Sauvager A. Ruffault C. David |
| Affiliation: | 1. Centre Régional de Lutte contre le Cancer, F-35 000, Rennes 2. Unité INSERM U 218, F-69008, Lyon 3. Laboratoire de microbiologie, UER Sciences médicales, F-35 000, Rennes, France 4. Services Vétérinaires Préfectoraux, F-35 000, Rennes, France |
| Abstract: | A heat-inactivated rough mutant of B. abortus increased resistance to a transplantable lymphoma when cultured on solid agar (ag) but not when cultured on a fluid medium (fl). The ag organisms were smaller, more toxic and induced more interferon 2 h after injection than fl. They also contained a phospholipid (cardiolipin) absent from fl preparations. |
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