Interfering PLD1-PED/PEA15 interaction using self-inhibitory peptides: An in silico study to discover novel therapeutic candidates against type 2 diabetes |
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| Authors: | Mohammad Hassan Baig Mohd Adnan Kausar Fohad Mabood Husain Shazi Shakil Irfan Ahmad Brijesh S. Yadav Mohd Saeed |
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| Affiliation: | 1. Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea;2. Department of Biochemistry, College of Medicine, University of Hail, Saudi Arabia;3. Department of Food Science and Nutrition, Faculty of Food and Agricultural Sciences, King Saud University, Saudi Arabia;4. Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;5. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;6. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia;g. Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia;h. Department of Bioengineering, University of Information Science and Technology, The Former Yugolav Republic of Macedonia;i. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Saudi Arabia;j. Research center for advanced materials science, King Khalid university, Abha, Saudi Arabia |
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| Abstract: | Diabetes type 2 (T2D) is a very complex disorder with a large number of cases reported worldwide. There are several reported molecular targets which are being used towards drug design. In spite of extensive research efforts, there is no sure shot treatment available. One of the major reasons for this failure or restricted success in T2D research is the identification of a major/breakthrough therapeutic target responsible for the progression of T2D. It has been well documented that one of the major causes mediating the insulin resistance is the interaction of PLD1 with PED/PEA15. Herein, we have performed in silico experiments to investigate the interaction between PLD1 with PED/PEA15. Furthermore, this study has explored pertinent molecular interactions involving the self-derived peptides. The peptides identified in this study are found to be capable of restricting the interaction of these two proteins. Accordingly, the study suggests that the “self-derived peptides” could be used as promising therapeutic candidate(s) against T2D. |
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| Keywords: | Diabetes Phospholipase D1 (PLD1) Phosphoprotein enriched in diabetes (PED/PEA15) Molecular interactions Peptides |
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