The association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer |
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| Authors: | Tianyuan Xiong Jiqiao Yang Haichuan Wang Fanyi Wu Yang Liu Rui Xu Zi Lv Pei Xue Wen Cao Yonggang Zhang |
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| Affiliation: | 1. West China Hospital/West China Medical School, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China
2. The Periodical Press of West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China
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| Abstract: | The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case–control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95–1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02–1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case–control studies are needed to validate our results. |
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