Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists |
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| Authors: | Guo Tao Gu Huizhong Hobbs Doug W Busler Dennis E Rokosz Laura L |
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| Affiliation: | Pharmacopeia Drug Discovery Inc., PO Box 5350, Princeton, NJ 08543-5350, USA. tguo@pcop.com |
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| Abstract: | Melanin concentrating hormone (MCH) plays an important role in the regulation of food intake and energy balance in mammals. MCH-1 receptor (MCH1R) deficient mice are lean and resistant to diet-induced obesity. As such, MCH1R antagonists are believed to have potential as possible treatments for obesity. The discovery of a novel class of tetralin ureas as potent MCH1R antagonists is described herein. |
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