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Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner) J. Agardh on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) |
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| Authors: | E Deslandes P Pondaven T Auperin C Roussakis C J Guézennec V Stiger C Payri |
| Institution: | (1) LEBAM-IUEM, Université de Bretagne Occidentale, place Nicolas Copernic, 29280 Plouzané, France;(2) Faculté des Sciences, ISOMer, 2 rue de la Houssinière, F44322 Nantes, Brittany, France;(3) Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachussetts 02115, USA;(4) IFREMER-DRV/EP/LBMH, 29280 Plouzané, France;(5) LEM, Université Française du Pacifique, Tahiti-P.F |
| Abstract: | An unusual sulfated fucan-like polysaccharidecontaining aminosugar constituent was isolated fromthe brown Fucales, Turbinaria ornata. Itsantiproliferative effect on asynchronous cells of ahuman non-small-cell bronchopulmonary carcinoma line(NSCLC-N6) was studied in vitro. The kinetics ofcell growth further to the continuous exposure ofcells to T. ornata extract was investigated andthe changes in the cell cycle were observed usingflow-cytometry. Cell growth appeared to be inhibitedin the G1 phase. Altogether our observations suggesta triggering of the terminal differentiation ofcancerous cells by this fucan-like polysaccharide. |
| Keywords: | fucan-like polysaccharide amino-sugar bronchopulmonary carcinoma antiproliferative effect cell cycle brown seaweed Turbinaria ornata |
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