A proposed role of superoxide anion as a biological nucleophile in the deesterification of phospholipids |
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| Authors: | Walter G. Niehaus |
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| Affiliation: | Department of Biochemistry and Nutrition, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 USA |
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| Abstract: | Potassium superoxide dissolved in dry dimethyl sulfoxide effects rapid deesterification of ethyl hexadecanoate and of dilauroyl phosphatidyl choline. The reaction with ethyl hexadecanoate is reversible, having an apparent equilibrium constant of 0.4. It is proposed that some of the deleterious effects on biological membranes which have been atributed to oxidation by superoxide may actually be the result of deesterification by superoxide acting as a nucleophile. |
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