Recent progresses on synthesized LuxS inhibitors: A mini-review |
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Authors: | Georges Mina Christiane Chbib |
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Institution: | 1. Pharmacy Department, Jackson Memorial Hospital, 1611 NW 12th Ave, Miami, FL 33136, United States;2. Department of Pharmaceutical Sciences, Larkin College of Pharmacy, 18301 North Miami Ave, Miami, FL 33169, United States |
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Abstract: | Design and synthesis of LuxS enzyme inhibitors otherwise known as S-ribosylhomocysteine analogues, to target quorum sensing in bacteria, has been considerably developed within the last decade. This review presents which molecules have been synthesized to target LuxS enzyme in other words inhibitors of S-ribosylhomocysteinase. It reports their tested biological activity as LuxS inhibitors when available. A systematic overview has been conducted by searching PubMed, Medline, and The Cochrane Library and data extraction of all synthesized S-ribosylhomocysteine analogues has been collected. This mini-review shows limited data to date on this area and should continue to be studied. |
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Keywords: | LuxS enzyme Quorum sensing Bacteria |
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