重组人促红素联合多糖铁复合物胶囊对全膝关节置换术患者血液指标、膝关节功能及生活质量的影响

摘要 目的：探讨重组人促红素联合多糖铁复合物胶囊对全膝关节置换术患者血液指标、膝关节功能及生活质量的影响。方法：选取我院2019年2月至2022年2月期间收治的150例全膝关节置换术患者,应用随机数字表法分为对照组（常规围术期处理,n=75）与研究组（重组人促红素+铁剂,n=75）。对比两组临床指标、血液指标、膝关节功能及生活质量。结果：研究组的失血量和输血量少于对照组,住院时间短于对照组（P<0.05）。两组治疗后平均红细胞体积（MCV）、血清铁蛋白（SF）、血红蛋白（Hb）及平均血红蛋白浓度（MCHC）均较治疗前升高,且研究组治疗后的MCV、SF、Hb、MCHC高于对照组（P<0.05）。两组治疗后膝关节Lequesne指数评分、膝关节WOMAC量表评分均较治疗前下降,且研究组治疗后的膝关节Lequesne指数评分、膝关节WOMAC量表评分低于对照组（P<0.05）。两组治疗后心理功能、物质生活、躯体功能以及社会功能均较治疗前升高,且研究组治疗后的心理功能、物质生活、躯体功能以及社会功能评分高于对照组（P<0.05）。结论：重组人促红素联合多糖铁复合物胶囊用于全膝关节置换术患者,可提升MCV、SF、Hb、MCHC水平,促进膝关节功能及生活质量改善。

Effects of Recombinant Human Erythropoietin Combined with Polysaccharide Iron Complex Capsule on Blood Indexes, Knee Joint Function and Quality of Life in Patients Undergoing Total Knee Arthroplasty

ABSTRACT Objective: To investigate the effects of recombinant human erythropoietin combined with polysaccharide iron complex capsule on blood indexes, knee joint function and quality of life in patients undergoing total knee arthroplasty. Methods: 150 patients with total knee arthroplasty who were treated in our hospital from February 2019 to February 2022 were selected, they were randomly divided into control group (routine perioperative treatment, n=75) and study group (recombinant human erythropoietin combined with iron, n=75) by random number table method. The clinical indexes, blood indexes, knee joint function and quality of life were compared between the two groups. Results: The blood loss volume and blood transfusion volume in the study group were less than those in the control group, and the hospital stay was shorter than that in the control group (P<0.05). The mean corpuscular volume (MCV), serum ferritin (SF), hemoglobin (Hb) and mean corpuscular hemoglobin concentration (MCHC) in the two groups after treatment were higher than those before treatment, and the MCV, SF, Hb and MCHC in the study group after treatment were higher than those in the control group (P<0.05). After treatment, the Lequesne index score and WOMAC score scale of the knee joint in the two groups decreased compared with those before treatment, and the Lequesne index score and WOMAC score scale of the knee joint in the study group after treatment were lower than those in the control group (P<0.05). After treatment, the scores of psychological function, material life, physical function and social function of the two groups were higher than those before treatment, and the scores of psychological function, material life, physical function and social function in the study group after treatment were higher than those in the control group (P<0.05). Conclusion: Recombinant human erythropoietin combined with polysaccharide iron complex capsule can improve the levels of MCV, SF, Hb and MCHC in patients undergoing total knee replacement, and promote the improvement of knee function and quality of life.