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NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon |
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| Authors: | Emilie Chauveau Virginie Doceul Estelle Lara Emmanuel Breard Corinne Sailleau Pierre-Olivier Vidalain Eliane F. Meurs Stéphanie Dabo Isabelle Schwartz-Cornil Stéphan Zientara Damien Vitour |
| Affiliation: | Maisons-Alfort Laboratory for Animal Health, ANSES, INRA, ENVA, UMR 1161 Virology, Maisons-Alfort, Francea;Unit of Viral Genomics and Vaccination, Institut Pasteur, CNRS URA 3015, Paris, Franceb;Unit of Hepacivirus and Innate Immunity, Institut Pasteur, CNRS URA 3015, Paris, Francec;Virologie et Immunologie Moléculaires, UR892 INRA, Jouy-en-Josas, Franced |
| Abstract: | Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system. |
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