| 益生元对口腔健康促进作用和机制研究进展 |
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| 引用本文： | 王冬雪,张倩霞,文艺,蒋文凯,王胜朝.益生元对口腔健康促进作用和机制研究进展[J].微生物学通报,2023,50(2):742-753. |
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| 作者姓名： | 王冬雪 张倩霞 文艺 蒋文凯 王胜朝 |
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| 作者单位： | 第四军医大学基础医学院二大队, 陕西 西安 710032;军事口腔医学国家重点实验室 口腔疾病国家临床医学研究中心 陕西省口腔医学重点实验室 第四军医大学口腔医院牙体牙髓病科, 陕西 西安 710032;军事口腔医学国家重点实验室 口腔疾病国家临床医学研究中心 陕西省口腔疾病临床医学研究中心 第四军医大学口腔医院正畸科, 陕西 西安 710032 |
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| 基金项目： | 军事口腔医学国家重点实验室课题(2020YF08，2021YF001)；第四军医大学医疗保健课题(2021KYBJ01) |
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| 摘 要： | 口腔微生物群落的动态平衡是维持口腔健康的关键因素。益生元是一类具有选择性、能够促进体内有益菌代谢增殖从而改善宿主健康的有机物质，主要通过调节口腔微生物生长代谢、抑制口腔菌斑生物膜形成、调节宿主免疫反应、参与硝酸盐-亚硝酸盐-一氧化氮代谢循环通路、调节氧化应激反应等途径调控口腔微生态，从而对口腔常见疾病，如龋齿、牙周病、口腔黏膜病的防治起到积极作用。本文主要就近年来益生元在口腔健康中的作用及相关机制的研究情况进行综述。
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| 关 键 词： | 益生元 口腔微生态 龋病 牙周病 口腔黏膜病 口腔微生物 |
| 收稿时间： | 2022/5/23 0:00:00 |
Improving effects and mechanisms of prebiotics on oral health: a review |
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| WANG Dongxue,ZHANG Qianxi,WEN Yi,JIANG Wenkai,WANG Shengchao.Improving effects and mechanisms of prebiotics on oral health: a review[J].Microbiology,2023,50(2):742-753. |
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| Authors: | WANG Dongxue ZHANG Qianxi WEN Yi JIANG Wenkai WANG Shengchao |
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| Institution: | Second Brigade, Basic Medical Science Academy, The Fourth Military Medical University, Xi''an 710032, Shaanxi, China;State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, The Fourth Military Medical University, Xi''an 710032, Shaanxi, China;State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi''an 710032, Shaanxi, China |
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| Abstract: | The balance of oral microbiota is a key factor in maintaining oral health. Prebiotics are a kind of organic substances that selectively promote the metabolism of beneficial microorganisms. They mainly exert their functions by adjusting the oral microbial growth and metabolism, inhibiting the formation of dental plaque biofilm, regulating the host immune response and oxidative stress response, and participating in the nitrate-nitrite-nitric oxide pathway. Studies have demonstrated that prebiotics play a positive role in the prevention and treatment of common oral diseases, such as dental caries, periodontal diseases, and oral mucosal disease, and are expected to become a potential way to prevent and treat oral diseases. This article reviews the recent research progress in prebiotics, their effects on oral health, and the mechanisms of prebiotics in regulating oral microecology. |
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| Keywords: | prebiotics oral microecology dental caries periodontal disease oral mucosal disease oral microorganism |
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