High-performance liquid chromatographic determination of α-keto acids in plasma with fluorometric detection |
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| Authors: | Tokishi Hayashi Hironori Tsuchiya Hiroshi Naruse |
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| Institution: | National Center for Nervous, Mental and Muscular Disorders, 2620, Ogawa-Higashi-Machi, Kodaira, Tokyo Japan |
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| Abstract: | This paper describes a sensitive high performance liquid chromatographic method for the quantitative determination of α-keto acids in plasma using a fluorescence detector. This method is about ten times more sensitive than that reported in a previous paper. Only 50 μl of plasma are needed for the determination of α-keto acids. However, p-hydroxyphenylpyruvic acid could not be analysed because the quinoxalinol derived from it does not exhibit fluorescence. |
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