Analysis of monomeric mutants of HSC70: a possible relationship between oligomerization and functional properties |
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| Authors: | Amor-Mahjoub Mouna Gomez-Vrielyunck Nathalie Suppini Jean Philippe Fouchaq Benoît Benaroudj Nadia Ladjimi Moncef |
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| Institution: | Laboratory of Biochemistry of Regulatory Signals, CNRS-University P&M Curie, 96 Bd Raspail, 75006, Paris, France. mounamor@yahoo.fr |
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| Abstract: | Data of this study showed that alphaD-alphaE helices and the conserved interdomain linker are two interfaces essential not only for the self-association but also for the functional properties of rat HSC70. Self-association which is a conserved property of HSP70 seems to be important for the activity of these proteins. |
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