Evolution of thedec-1 eggshell locus inDrosophila. II. Intraspecific DNA sequence analysis reveals length mutations in a repetitive region inD. melanogaster |
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Authors: | Stefan Andersson Andrew Lambertsson |
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Institution: | (1) Department of Genetics, University of Umeå, S-901 87 Umeå, Sweden;(2) Department of Biology, Division of General Genetics, University of Oslo, P.O. Box 1031 Blindern, N-0315 Oslo, Norway |
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Abstract: | Summary Thedec-1 eggshell gene inDrosophila melanogaster encodes follicle cell proteins required for proper eggshell assembly. As shown by Southern and Northern analyses thedec-1 gene occurs in four alleles (Fcl-4) among wild-type strains. Its second exon has a distinct feature in the form of 12 repeats with 78–91 nucleotides; the first five show nearly 100% homology. DNA sequence comparison of the repeated region of the alleles revealed that the length polymorphisms are caused by changes in the numbers of the first five repeats. The results suggest that the alleles have been generated by unequal intragenic crossing-over and/or slippage during DNA replication and that the allelic length variants have arisen independently. The possiblilty that the most common allele,FC1, has a selective advantage over the other alleles is discussed. |
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Keywords: | Drosophila dec-1 eggshell gene Wild-type variants Repeated region DNA sequencing |
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