Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: A technical note |
| |
Authors: | K P R Chowdary Y Srinivasa Rao |
| |
Institution: | (1) Industrial Pharmacy Division, Department of Pharmaceutical Sciences, Andhra University, 530 003 Visakhapatnam, India |
| |
Abstract: | Conclussion Thus, large spherical microcapsules with a coat consisting of alginate and a mucoadhesive polymer (sodium CMC, methylcellulose,
Carbopol, or HPMC) could be prepared by an orifice-ionic gelation process. The microcapsules exhibited good mucoadhesive properties
in an in vitro test. Glipizide release from these mucoadhesive microcapsules was slow and extended over longer periods of
time and depended on composition of the coat. Drug release was diffusion controlled and followed zero-order kinetics after
a lag, period of 1 hour. In the in vivo evaluation, alginate-Carbopol microcapsules could sustain the hypoglycemic effect
of glipizide over a 14-hour period. These mucoadhesive microcapsules are, thus, suitable for oral controlled release of glipizide. |
| |
Keywords: | mucoadhesive microcapsules glipizide controlled release |
本文献已被 PubMed SpringerLink 等数据库收录! |
|