Morphinandienone and aporphine alkaloids from Corydalis decumbens |
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| Institution: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia;3. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;4. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;5. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;6. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt;1. Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an, 223003, China;2. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China;3. School of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China;4. Ocean College, Zhejiang University, Hangzhou, 310058, China;1. Weinan Central Hospital, Shengli Rd, Weinan, 714000, PR China;2. Shaanxi University of Chinese Medicine, Western Century Avenue, Xianyang, 712046, PR China;1. Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa;2. School of Pharmacy, University of Namibia, Private Bag 13301, Windhoek, Namibia;3. Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, 6140, South Africa;4. Department of Chemistry, The University of Western Ontario, London, Ontario, N6A 5B7 Canada;5. Department of Biological Sciences, University of Cape Town, Private Bag, Rondebosch, South Africa;6. Department of Chemistry, University of the Western Cape, Bellville, 7535, South Africa;7. School of Pharmacy, University of the Western Cape, Bellville, 7535, South Africa |
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| Abstract: | Phytochemical examination of Corydalis decumbens has afforded two new morphinandienone alkaloids, namely, (-)-pallidine N-oxide (1) and (-)-salutaridine N-oxide (2), together with one known analogue, (-)-pallidine (3), and three known aporphine alkaloids (4?6). Their structures were elucidated via comprehensive spectroscopic analysis and chemical correlation. This study represents the first isolation of morphinandienone alkaloids from the title plant. All isolates were tested for their activities towards neuronal excitability in primary cultured neocortical neurons. |
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| Keywords: | Morphinandienone Chemical correlation Neuronal excitability |
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