Botanical origin of triterpenoids from Yucatecan propolis |
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| Institution: | 1. Laboratorio de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Chuburná de Hidalgo, CP 97205, Mérida, Yucatán, México;2. Unidad de Recursos Naturales, Centro de Investigación Científica de Yucatán, Calle 43 No. 130, Chuburná de Hidalgo, CP 97205, Mérida, Yucatán, México;3. SONAS EA921, SFR4207 QUASAV, University of Angers, 42, rue Georges Morel 49070, Beaucouzé, France;1. Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai’an, 223003, China;2. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China;3. School of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China;4. Ocean College, Zhejiang University, Hangzhou, 310058, China;1. Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Freiburg, 79085, Germany;2. Centro Nacional de Innovaciones en Biotecnológicas, Pavas, 1174-1200, Costa Rica;3. Escuela de Biología, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;4. Centro de Investigación en Biología Celular y Molecular and Escuela de Química. Universidad de Costa Rica, San José, 11501-2060, Costa Rica;5. Centro de Investigaciones en Productos Naturales and Escuela de Química. Universidad de Costa Rica, San José, 11501-2060, Costa Rica;6. Instituto de Investigaciones Farmacéuticas, Facultad de Farmacia, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand;2. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China;1. Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa;2. School of Pharmacy, University of Namibia, Private Bag 13301, Windhoek, Namibia;3. Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, 6140, South Africa;4. Department of Chemistry, The University of Western Ontario, London, Ontario, N6A 5B7 Canada;5. Department of Biological Sciences, University of Cape Town, Private Bag, Rondebosch, South Africa;6. Department of Chemistry, University of the Western Cape, Bellville, 7535, South Africa;7. School of Pharmacy, University of the Western Cape, Bellville, 7535, South Africa |
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| Abstract: | Propolis is a resinous material produced by bees from plant exudates; the most common secondary metabolites found in propolis are poliphenolics with different biological activities. Nevertheless, to date, there are a number of reports describing the presence of triterpenoids in propolis. This work describes the isolation and identification of the triterpenoids mangiferolic acid (1), iso-mangiferolic acid (2), and dammarenediol II (3), together with a number of ubiquitous pentacyclic triterpenes, from the extract of a propolis sample collected in Yucatan, Mexico. While the cycloartanes 1 and 2 have been reported previously from propolis samples collected in Africa, Asia and South America, this is the first report of 3 as a component in propolis. The botanical origin of 3 and the pentacyclic triterpenes has been traced to the resin of Bursera simaruba, a tree commonly found in Yucatan peninsula. The results of this investigation confirm the close relationship between the flora surrounding the beehive and the chemical composition of propolis. |
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| Keywords: | Cycloartanes Dammarennediols |
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