New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2 |
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| Institution: | 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;2. School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China;3. Key Laboratory of Functional Molecules from Oceanic Microorganisms, Sun Yat-sen University, Department of Education of Guangdong Province, Guangzhou 510080, China;4. South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China;5. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China |
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| Abstract: | Chemical investigation of the mangrove-derived fungus Aspergillus sp. AV-2 following fermentation on solid rice medium led to the isolation of a new phenyl pyridazine derivative (1) and a new prenylated benzaldehyde derivative, dioxoauroglaucin (2), together with fourteen known compounds (3-16). Chemical structures of the new compounds were unambiguously determined based on HRESIMS and extensive 1D and 2D NMR spectroscopic analyses. Compounds 2-7, 8 and 13 were assessed for their antiproliferative activity against Caco-2 cell lines, where flavoglaucin (6) revealed the most potent cytotoxicity with IC50 of 2.87 μM. |
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| Keywords: | Mangrove Endophyte Prenylated benzaldehyde Pyridazine Antiproliferative activity |
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