|
|||||
|
|
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
|
| Authors: | Aster Susan D Graham Donald W Kharbanda Divya Patel Gool Ponpipom Mitree Santorelli Gina M Szymonifka Michael J Mundt Steven S Shah Kashmira Springer Marty S Thieringer Rolf Hermanowski-Vosatka Anne Wright Samuel D Xiao Jianying Zokian Hratch Balkovec James M |
| Institution: | aDepartment of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA bDepartment of Cardiovascular Disease, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA |
| Abstract: | 3-Aryl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active in both in vitro and an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented. |
| Keywords: | 11β-Hydroxysteroid dehydrogenase Metabolic syndrome Bis-aryl triazoles |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |