LIM proteins: association with the actin cytoskeleton |
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Authors: | T. Khurana B. Khurana A. A. Noegel |
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Affiliation: | (1) Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, DE |
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Abstract: | The LIM domain is an evolutionary conserved double-zinc finger motif found in a variety of proteins exhibiting diverse biological roles. LIM domains have been observed to act as modular protein-binding interfaces mediating protein-protein interactions in the cytoplasm and the nucleus. Interaction of LIM domains with specific protein partners is now known to influence its subcellular localization and activity; however, no single binding motif has been identified as a common target for LIM domains. Several LIM domain-containing proteins associated with the actin cytoskeleton have been identified, playing a role in signal transduction and organization of the actin filaments during various cellular processes. |
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Keywords: | : Cysteine-rich proteins Myogenesis Focal adhesion Enigma proteins LIM kinases Dictyostelium discoideum. |
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