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Effect of amygdaloid kindling on rat striatal dopamine D1- and D2-receptors |
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| Authors: | R Allin M Mintz V Russell A Engelbrecht M Lamm W Daniels G van der Spuy A Jaffer L Kellaway J Taljaard |
| Institution: | (1) MRC Research Unit for the Neurochemistry of Mental Diseases, Department of Chemical Pathology, University of Stellenbosch, P.O. Box 19113, 7505 Tygerberg, RSA;(2) Psychobiology Research Unit, Department of Psychology, Tel-Aviv University, 69978 Ramat-Aviv, Israel;(3) Department of Physiology, University of Capa Town, 7925 Observatory, RSA |
| Abstract: | The effect of kindling on dopaminergic (DA) neurotransmission was assessed by measuring dopamine D1- and D2-receptor binding in the dorsal and ventral striatum of rats either 2 hours (short-term) or 3–4 weeks (long-term) after the last kindled seizure. Kindling did not have any significant long-term effect on DA D2-receptor Kd or Bmax values in the dorsal or ventral striatum or on DA D1-receptor parameters in the dorsal striatum. The short-term effect of kindled seizures was to abolish the asymmetry in DA D2-receptor density observed in the dorsal striatum of control rats. DA D1-receptor density was also increased in the dorsal striatum contralateral to the kindled amygdala of short-term rats. The short-term effects support the notion that limbic seizures can modify the lateral imbalance of DA activity in the striatum. |
| Keywords: | Amygdala kindling striatum dopamine D1- and D2-receptors |
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