Novel lysophospholipase A secreted by Legionella pneumophila |
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| Authors: | Flieger A Gong S Faigle M Stevanovic S Cianciotto N P Neumeister B |
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| Affiliation: | Abteilung für Transfusionsmedizin, Universit?tsklinikum Tübingen, Universit?t Tübingen, D-72076 Tübingen, Germany. a-flieger@northwestern.edu |
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| Abstract: | We show that Legionella pneumophila possesses lysophospholipase A activity, which releases fatty acids from lysophosphatidylcholine. The NH2-terminal sequence of the enzyme contained FGDSLS, corresponding to a catalytic domain in a recently described group of lipolytic enzymes. Culture supernatants of a L. pneumophila pilD mutant lost the ability to cleave lysophosphatidylcholine. |
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