Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis |
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| Authors: | Xiaochun Xia Baixia Yang Xiaogang Zhai Xiangyang Liu Kang Shen Zhijun Wu Jing Cai |
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| Institution: | 1. Department of Radiation Oncology, Nantong Tumor Hospital, Nantong, Jiangsu, China.; 2. Department of Nuclear Medicine, Nantong Tumor Hospital, Nantong, Jiangsu, China.; 3. Department of Science and Education, Nantong Tumor Hospital, Nantong, Jiangsu, China.; Queen Elizabeth Hospital, Hong Kong, |
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| Abstract: | BackgroundTo date, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. The present meta-analysis summarizes the recent advances in the use of microRNA-21 (miR-21) in the assessment of colorectal cancer and analyzes the prognostic role of miR-21 for survival outcome.Methodology/Principal FindingsThe present meta-analysis was performed by searching PubMed through multiple search strategies. Data were extracted from studies comparing overall survival (OS) in patients with colorectal cancer who showed higher expression of miR-21 than similar patients. Pooled hazard ratios (HRs) of miR-21 for survival and 95% confidence intervals (CI) were calculated. Seven studies with a total of 1174 patients were included this meta-analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR-21 expression in colorectal cancer was 1.76 (95% CI: 1.34–2.32, P=0.000). After elimination of heterogeneity, the pooled HR was 2.32 (95% CI: 1.82–2.97, P=0.000), which was found to significantly predict poorer survival. The subgroup analysis suggested that elevated miR-21 level and patients’ survival correlated with III/IV stage (HR=5.35, 95% CI: 3.73–7.66).Conclusions/SignificanceThe present findings suggest that high expression of miR-21 might predict poor prognosis in patients with colorectal cancer. |
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