Front Cover: Dynamic observation and quantification of type I/II collagen in chondrogenesis of mesenchymal stem cells by second‐order susceptibility microscopy (J. Biophotonics 2/2019)
Abstract:
Top row is time‐lapse, multiphoton imaging of induced chondrogenesis from stem cells. The second row shows the time‐lapse second harmonic generation imaging of generated collagen. However, only the third row of second order susceptibility imaging allows the differentiation of the content of the two types of collagen (I and II) that were produced over time. The method allows the noninvasive and label‐free discrimination of different collagen species in real time and can be used for quality control in tissue engineering. Further details can be found in the article by Chiu‐Mei Hsueh, Hung‐Ming Lin, Te‐Yu Tseng, et al. ( e201800097 ).
