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Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I |
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| Authors: | Bergman J M Abrams M T Davide J P Greenberg I B Robinson R G Buser C A Huber H E Koblan K S Kohl N E Lobell R B Graham S L Hartman G D Williams T M Dinsmore C J |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. |
| Abstract: |  A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibition of Ki-Ras signaling. |
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