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αγ-Enolase in the Rat: Ontogeny and Tissue Distribution
Authors:Ole Steen Jø  rgensen,Gyda Centervall
Affiliation:University of Copenhagen, Psychochemistry Institute, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark
Abstract:
Abstract: The rat brain enolases are dimers composed of α and γ subunits. At pH 8.6 αγ-enolase seemed to be stable, and no evidence was found for the possible formation of αγ-enolase from αα-enolase and γγ-enolase in the course of rat brain homogenization. During ontogeny of the rat forebrain, αγ-enolase was formed before γγ-enolase. The half-maximal specific concentrations were reached at postnatal days 14 and 23, respectively. The distribution of αγ- and γγ-enolase in various rat brain areas was also investigated. In all areas both forms were present. In neuroendocrine tissues αγ-enolase was present at a much higher concentration than γγ-enolase. The ratio between γγ-enolase and αγ-enolase may be indicative of the degree of neuronal maturation, a conclusion further substantiated by the high ratio observed in cerebellum and the low ratio observed in olfactory bulbs, both compared with the ratio in forebrain.
Keywords:αγ-Enolase    γγ-Enolase    Ontogeny    Tissue distribution    Rat
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