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Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway
Authors:Richard J Mills  Benjamin L Parker  Gregory A Quaife-Ryan  Holly K Voges  Elise J Needham  Aurelie Bornot  Mei Ding  Henrik Andersson  Magnus Polla  David A Elliott  Lauren Drowley  Maryam Clausen  Alleyn T Plowright  Ian P Barrett  Qing-Dong Wang  David E James  Enzo R Porrello  James E Hudson
Institution:1. School of Biomedical Sciences, The University of Queensland, St Lucia 4072, QLD, Australia;2. Centre for Cardiac and Vascular Biology, The University of Queensland, St Lucia 4072, QLD, Australia;3. QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia;4. Charles Perkins Centre, School of Life and Environmental Science, The University of Sydney, Sydney 2006, NSW, Australia;5. Discovery Sciences, IMED Biotech Unit, AstraZeneca Cambridge, Cambridge, UK;6. Discovery Sciences, IMED Biotech Unit, AstraZeneca Gothenburg, Gothenburg, Sweden;7. Medicinal Chemistry, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Gothenburg, Sweden;8. Murdoch Children’s Research Institute, The Royal Children’s Hospital, Parkville 3052, VIC, Australia;9. Bioscience Heart Failure, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Gothenburg, Sweden;10. Department of Physiology, School of Biomedical Sciences, The University of Melbourne, Parkville 3010, VIC, Australia
Abstract:
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  • Keywords:Corresponding author  organoid  pluripotent stem cells  drug development  cardiomyocyte proliferation  statin  cholesterol
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