Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients |
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| Authors: | Agung A. Wibowo Bambang Pardjianto Sutiman B. Sumitro Nia Kania Kusworini Handono |
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| Affiliation: | 1. Doctoral Program in Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia;2. Department of Surgery, Ulin General Hospital, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;3. Department of Plastic Surgery, Faculty of Medicine Universitas Brawijaya/dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia;4. Department of Biology, Faculty of Sciences, Universitas Brawijaya Malang, East Java, Indonesia;5. Department of Pathology, Ulin General Hospital, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia;6. Department of Clinical Pathology, Faculty of Medicine Universitas Brawijaya/dr.Saiful Anwar General Hospital, Malang, East Java, Indonesia |
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| Abstract: | IntroductionThe involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients.MethodsA total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis patients. MUC2 mutation analysis was carried out using immunofluorescent and FISH techniques. Assessment of caspase-3, Ki-67, NF-kB, and lectin expressions was also carried out by immunofluorescent technique then analyzed by confocal laser scanning microscope.ResultsThe MUC2, caspase-3, and lectin expressions were significantly lower in the colitis group than in the control group (p < 0.05).ConclusionsIt was concluded that in colitis there was a change in MUC2 expression due to changes in lectins accompanied by apoptotic defects.conclusion |
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| Keywords: | Mucin Inflammation Apoptosis Lectin Colon |
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