Ions and blockers in potassium channels: insights from free energy simulations |
| |
Authors: | Luzhkov V B Aqvist J |
| |
Institution: | Department of Cell and Molecular Biology, Uppsala University, BMC, Box 596, S-751 24 Uppsala, Sweden. |
| |
Abstract: | Potassium ion channels enable efficient and selective permeation of K+ ions across nonpolar biological membranes. Here we review the results of recent free energy calculations related to the permeation of monovalent cations through K+ channels and to the channel inhibition by blocker compounds. In particular, the progress in computational studies of the bacterial KcsA channel is discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|