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Intestinal barrier function in response to abundant or depleted mucosal glutathione in Salmonella-infected rats |
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| Authors: | Marleen TJ van Ampting Arjan J Schonewille Carolien Vink Robert Jan M Brummer van der Roelof Meer Ingeborg MJ Bovee-Oudenhoven |
| Affiliation: | 1. TI Food and Nutrition, Wageningen, the Netherlands 2. Department of Health and Safety, NIZO food research, Ede, the Netherlands 3. Nutrition and Toxicology Research institute Maastricht, Maastricht University, Maastricht, the Netherlands 4. School of Health and Medical Sciences, ?rebro University, ?rebro, Sweden |
| Abstract: | BackgroundGlutathione, the main antioxidant of intestinal epithelial cells, is suggested to play an important role in gut barrier function and prevention of inflammation-related oxidative damage as induced by acute bacterial infection. Most studies on intestinal glutathione focus on oxidative stress reduction without considering functional disease outcome. Our aim was to determine whether depletion or maintenance of intestinal glutathione changes susceptibility of rats to Salmonella infection and associated inflammation. |
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