Comparative evaluation under routine conditions of the nitrate reduction assay, the proportion assay and the MGIT 960 assay for drug susceptibility testing of clinical isolates of Mycobacterium tuberculosis |
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| Authors: | Fonseca Leila de Souza Vieira Gisele Betzler de Oliveira Sobral Luciana Fonseca Ribeiro Elizabete Oliveira Marsico Anna Grazia |
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| Institution: | Laboratório de Micobacteriologia, Complexo Hospitalar Instituto de Doen?as do Tórax/Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brasil. lsfonseca@micro.ufrj.br |
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| Abstract: | The performance of the nitrate reductase assay (NRA) was compared with the proportion method (PM) on Lowenstein-Jensen medium and the BACTEC MGIT960 assay under routine conditions using 160 clinical isolates of Mycobacterium tuberculosis with a high proportion of resistant strains. The mean time to obtain results was 8.8 days and the overall agreements between NRA and PM and NRA and M960 were 95% and 94%, respectively. NRA was easy to perform and represents a useful tool for the rapid screening of drug-resistant M. tuberculosis strains in low-resource countries. |
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