首页 | 本学科首页   官方微博 | 高级检索  
     


Growth/differentiation 5 promotes the differentiation of retinal stem cells into neurons via Atoh8
Authors:Yanxiu Li  Haibo Li  LuSi Zhang  Siqi Xiong  ShiJin Wen  Xiaobo Xia  Xia Zhou
Affiliation:1. Department of Ophthalmology, The Xiangya Hospital, Central South University, Changsha, Hunan, China

Yan-xiu Li and Hai-bo Li contributed equally to this study.;2. Department of Ophthalmology, The Xiangya Hospital, Central South University, Changsha, Hunan, China;3. The School of Life Sciences, Central South University, Changsha, Hunan, China

Abstract:Retinal diseases are characterized by the degeneration of retinal neural cells, and are the main cause of blindness. Although the development of stem cell including retinal stem cell therapies raises hope for retinal neuron replacement, currently, there is still no efficient method to regenerate retinal neurons. To realize the potential roles of the production of retinal neurons, neurotrophic factor direct the differentiation of retinal stem cells should be extensively identified. In this article, we characterized growth/differentiation 5 (GDF5), which caused the activation of Smad signaling, can induce neurogenesis and neurite outgrowth in retinal stem cell differentiation. Moreover, a bHLH transcription factor, Atoh8 modulates the effects stimulated by GDF5. These data suggested that GDF5 regulates neuron differentiation through mediating Atoh8 and help us to understand the pathophysiological function of GDF5 in retinal regeneration.
Keywords:Atoh8  growth/differentiation 5  neuron differentiation  retinal stem cells
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号