|
|||||
|
|
Toll-like receptors in the functional orientation of cardiac progenitor cells |
|
| Authors: | Mohammadreza Yousefi Mina Mamipour Sadiye E Sokullu Shahrooz Ghaderi Hassan Amini Reza Rahbarghazi |
| Institution: | 1. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Research Center for Translational Medicine, Koç University, Istanbul, Turkey Mohammadreza Yousefi and Mina Mamipour are considered as the co-first author.;2. Engineering Sciences, Bioengineering Department, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir, Turkey;3. Department of System Physiology, Ruhr University, Bochum, Germany;4. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Department of General and Vascular Surgery, Tabriz University of Medical Sciences, Tabriz, Iran;5. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| Abstract: | Cardiac progenitor cells (CPCs) have the potential to differentiate into several cell lineages with the ability to restore in cardiac tissue. Multipotency and self-renewal activity are the crucial characteristics of CPCs. Also, CPCs have promising therapeutic roles in cardiac diseases such as valvular disease, thrombosis, atherosclerosis, congestive heart failure, and cardiac remodeling. Toll-like receptors (TLRs), as the main part of the innate immunity, have a key role in the development and differentiation of immune cells. Some reports are found regarding the effect of TLRs in the maturation of stem cells. This article tried to find the potential role of TLRs in the dynamics of CPCs. By showing possible crosstalk between the TLR signaling pathways and CPCs dynamics, we could achieve a better conception related to TLRs in the regeneration of cardiac tissue. |
| Keywords: | cardiac progenitor cells cell dynamics functional behavior toll-like receptor |