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Prospect of circular RNA in osteogenesis: A novel orchestrator of signaling pathways |
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| Authors: | Xinqi Huang Xiao Cen Bo Zhang Yuwei Liao Guanyin Zhu Jun Liu Zhihe Zhao |
| Institution: | 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China
Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Xinqi Huang and Xiao Cen contributed equally to this study.;2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China Department of Temporomandibular Joint, West China Hospital of Stomatology, Sichuan University, Chengdu, China Xinqi Huang and Xiao Cen contributed equally to this study.;3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China;4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China |
| Abstract: | Circular RNAs (circRNAs) were initially regarded as by-products of aberrant splicing. But now, there are substantial evidence on their various roles in the regulation of genes during the development of organs and diseases. Consistent with these breakthroughs, it is experiencing rapid growth that circRNAs function as the important checkpoints during the osteogenesis. Therefore, characterizing the roles of circRNAs is useful and critical to better understanding the process of osteogenic differentiation, which could provide new avenues for the diagnosis and treatment of bone diseases, such as bone defects and osteoporosis. In this review, we presented a map of the interaction between circRNAs and the molecules of signaling pathways associated with osteogenesis, summarized the current knowledge of the biological functions of circRNAs during the osteogenic differentiation, figured out the limits of existing research works, and provided a novel look on the diagnostic and therapeutic methods of bone diseases based on circRNAs. |
| Keywords: | circular RNAs microRNAs mRNAs osteogenesis |