Ependymal Cell Differentiation and GLUT1 Expression
is a Synchronous Process in the Ventricular Wall |
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| Authors: | Carmen Silva-Alvarez Mónica Carrasco Carolina Balmaceda-Aguilera Patricia Pastor María de los Angeles García Karin Reinicke Luis Aguayo Benedicto Molina Manuel Cifuentes Rodolfo Medina Francisco Nualart |
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| Institution: | (1) Laboratorio de Neurobiología Celular, Departamento de Biología Celular Facultad de Ciencias Biológicas, Universidad de Concepción, casilla 160C, Concepción, Chile;(2) Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile;(3) Departamento de Ciencias Básicas, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile;(4) Departamento de Biología Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain;(5) Department of Basic Medical Sciences, St. George’s, University of London, SW17 0RE London, UK |
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| Abstract: | Ependymal cells appear to be totally differentiated during the first 3 weeks in the mouse brain. Early during postnatal development
ependymal cells differentiate and undergo metabolic activation, which is accompanied by increased glucose uptake. We propose
that ependymal cells induce an overexpression of the glucose transporter, GLUT1, during the first 2 weeks after delivery in
order to maintain the early metabolic activation. During the first postnatal day, GLUT1 is strongly induced in the upper region
of the third ventricle and in the ventral area of the rostral cerebral aqueduct. During the next 4 days, GLUT1 is expressed
in all differentiated ependymal cells of the third ventricle and in hypothalamic tanycytes. At the end of the first week,
ependymal cell differentiation and GLUT1 overexpression is concentrated in the latero-ventral area of the aqueduct. We propose
that ependymal cell differentiation and GLUT1 overexpression is a synchronous process in the ventricular wall. |
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| Keywords: | Cerebral aqueduct ependymal cells GLUT1 ventricular zone SCO |
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