A new solid-phase synthesis of oligonucleotides 3'-conjugated with peptides |
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| Authors: | De Napoli L Messere A Montesarchio D Piccialli G Benedetti E Bucci E Rossi F |
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| Affiliation: | Dipartimento di Chimica Organica e Biologica, Università degli Studi di Napoli Federico II, Italy. |
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| Abstract: | ![]()
A convenient 'on line' solid-phase synthesis of oligonucleotides conjugated at the 3'-end with peptides by means of a polymeric support linking the first nucleoside via the base has been developed. A 17-mer designed for antisense experiments against HIV-1, linking at the 3'-terminus the tripeptide Gly-Gly-His, was prepared in good yields and characterized by MALDI-TOF mass spectrometry. |
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