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AATF/Che‐1 acts as a phosphorylation‐dependent molecular modulator to repress p53‐driven apoptosis
Authors:Safiya Khurshid  Shuhua Chen  Pia Hasskamp  Tamina Seeger‐Nukpezah  Katharina Schilberg  Lukas Heukamp  Tobias Lamkemeyer  Martin L Sos  Roman K Thomas  Drew Lowery  Frederik Roels  Matthias Fischer  Max C Liebau  Ulrike Resch  Tülay Kisner  Fabian Röther  Malte P Bartram  Roman Ulrich Müller  Francesca Fabretti  Peter Kurschat  Björn Schumacher  Matthias Gaestel  René H Medema  Michael B Yaffe  Bernhard Schermer  Thomas Benzing
Institution:1. Department II of Internal Medicine, University Hospital of Cologne, , Cologne, Germany;2. Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD), University of Cologne, , Cologne, Germany;3. Department I of Internal Medicine, University Hospital of Cologne, , Cologne, Germany;4. Institute of Pathology, University of Cologne, , Cologne, Germany;5. Max Planck Institute for Neurological Research with Klaus‐Joachim‐Züls‐Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, , Cologne, Germany;6. Department of Translational Genomics, University of Cologne, , Cologne, Germany;7. Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, , San Francisco, CA, USA;8. Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research, , Cambridge, MA, USA;9. Department of Pediatrics, University Hospital of Cologne, , Cologne, Germany;10. Center for Molecular Medicine Cologne, University of Cologne, , Cologne, Germany;11. Department of Dermatology, University Hospital of Cologne, , Cologne, Germany;12. Systems Biology of Aging, University of Cologne, , Cologne, Germany;13. Institute of Physiological Chemistry, Hannover Medical University, , Hannover, Germany;14. Division of Cell Biology, The Netherlands Cancer Institute, , Amsterdam, The Netherlands
Abstract:
Keywords:AATF  apoptosis  checkpoint  DNA damage  kinase signalling  MK2  p53
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