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Ontogeny of hemoglobins: Evidence for hemoglobin M |
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| Authors: | Robert W Keane Ursula K Abbott JLynne Brown Vernon M Ingram |
| Institution: | 1. Department of Avian Sciences, University of California, Davis, California CA, 95616 USA;2. Department of Microbiology and Immunology, Albert Einstein School of Medicine, Bronx, New York 10461 USA;3. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA |
| Abstract: | A new autosomal codominant hemoglobin mutation alters hemoglobin M of the primitive red cell line and hemoglobin D found in definitive cells. That Hb M and Hb D are altered by the same gene mutation supports the idea that Hb M shares a polypeptide chain with Hb D. It is concluded that in the switch from primitive hemoglobins to those of the definitive type, there are at least two α chains conserved; αA of Hb E in Hb A and αD of Hb M in Hb D. |
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