Synthesis of a peptidocalix[4]arene library and identification of compounds with hydrolytic activity |
| |
| Authors: | Brewster R Elizabeth Dalton Brian G A Shuker Suzanne Beckham |
| |
| Affiliation: | School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30329-0400, USA. |
| |
| Abstract: | A 120 member library of peptidocalix[4]arenes was synthesized and screened for catalysis of the hydrolysis of p-nitrophenyl acetate. His-Ser-His-calix[4]arene was found to catalyze this reaction with v(0)=3.24 x 10(-8)M/s, an increase of 1520% above background and 30% above the tripeptide (His-Ser-His) alone. |
| |
| Keywords: | Calixarenes Catalysis Solid-phase synthesis Amino acids Peptides |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
