Medium Isotope Effect in [3H]Diazepam Binding to Benzodiazepine Receptors of Synaptic Membranes |
| |
| Authors: | J. Kardos,I. Ková cs,M. Simonyi |
| |
| Affiliation: | Central Research Institute for Chemistry, The Hungarian Academy of Sciences, Budapest, Hungary |
| |
| Abstract: | Replacement of H2O by D2O resulted in significantly higher amount of [3H]diazepam specifically bound to synaptic membranes. The isotope effect arises from increased number of binding sites in D2O and is associated with a stronger solvation of membrane receptors by heavy water. |
| |
| Keywords: | Synaptic membrane receptors [3H]Diazepam binding D2O Isotope effect |
|
