EARLY CHANGES IN ACETYLCHOLINE POOLS IN THE HIPPOCAMPUS OF THE RAT BRAIN AFTER SEPTAL LESIONS |
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| Authors: | Anna Potempska Malgorzata Gr&#;dkowska Barbara Oderfeld-Nowak |
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| Institution: | Department of Biochemistry of Nervous System and Muscle, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, 02–093 Warsaw, Poland |
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| Abstract: | —After placement of lesions in the hippocampus by electrocoagulation, an increase in bound acetylcholine above control levels was shown. There was no concomitant rise in free acetylcholine. The rise in bound acetylcholine was not due to changes in levels of either acetylcholinesterase or choline acetyltransferase and it is suggested that the interruption of septal impulses and/or alterations in uptake or availability of substrates is responsible. |
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